The time for hepatitis B patients to develop liver fibrosis is uncertain, and is related to whether the patient is actively treated and the severity of the disease, so it is not possible to make a generalization. Liver fibrosis is a stage in the progression of chronic liver disease to cirrhosis. If hepatitis B patients are well controlled through active and timely treatment, liver fibrosis usually does not occur. However, if the condition of hepatitis B patients is severe, or chronic hepatitis B patients, when the treatment is not timely, it will be easy to promote the infiltration of inflammatory cells and the release of inflammatory factors, which will promote the fibrosis of the liver. However, the specific time has individual variability, some patients appear liver fibrosis in about 1 year, some patients appear in about 5 years, and there is not a clear value. It is recommended that patients with hepatitis B actively cooperate with their doctors to improve their prognosis and minimize complications as much as possible.