Drug therapy is one of the most common and important measures in pediatric clinical treatment. Compared with adults, children have unique anatomical and physiological characteristics and are a growing and developing individual. The process of maturation of various physiological functions is also in progress. Because of this fact, the pharmacokinetics of the same drug in children is very different from that of adults, and pediatric drug use is bound to have its own special characteristics and principles that should be followed. 1, the clarity of diagnosis: before treatment should be as clear as possible diagnosis, only a clear diagnosis, to ensure the accuracy of drug selection, which is the premise of drug therapy. 2, the effectiveness of drugs: after the diagnosis is clear, choose the effective drugs that target the cause or improve the main symptoms and block the main pathogenic damage, and calculate the dosage. In addition, choose the route of administration, the method of administration and the course of treatment to ensure the best treatment process. 3, the safety of drugs: children’s medicine in addition to the requirements of good efficacy, fast results, more importantly, there is the safety of drugs, compared to adults, this aspect is very high requirements, many drugs are very effective, but there are large toxic side effects, or special toxic effects on children, pediatrics can not be used. Such as quinolones is a very effective antibacterial drugs, because it may lead to pediatric bone and joint damage, children can not be used. 4, medication compliance: refers to the degree of acceptance of the drug by the child, which is very important in pediatrics, the adage of “advice is better than action, and bitterness is better than disease” has no value for children. It is difficult for children to consciously and actively overcome the discomfort (abnormal taste or pain, etc.) brought by the medication process, and they often refuse treatment, and strong resistance is prone to accidental injury and psychological trauma. For oral drugs as far as possible, choose the dosage form for children of different ages. For small infants, granules and oral liquids are often used, and special attention should be paid to choosing the right taste and color for children, and trying to choose drugs with a longer half-life to reduce the number of doses. Intravenous administration of drugs can be left cannula needle, reduce the number of puncture, adjust the appropriate infusion speed, minimize the discomfort caused by the treatment process to children, do more induction work for older children, as far as possible to take the initiative to accept treatment, to achieve the purpose of improving compliance. 5, the more expensive the drug, the better the viewpoint, a drug is good, first of all, to see whether it is the right symptoms, followed by the efficacy, three is the size of toxic side effects, these three aspects are good, try to choose the best inexpensive drugs. 6, dosage, efficacy science: the dosage of drugs is based on scientific research and a large number of clinical trials to determine, taking into account the effectiveness and safety, can not be arbitrarily increased or reduced. The length of the course of medication is mainly based on the characteristics of the drug itself, the disease of the lightness of the results of comprehensive consideration, small doses, short courses of treatment can not achieve the expected efficacy, easy to relapse, large doses, the course of treatment, may bring more side effects and damage to children, the dose, usage and course of medication must be in accordance with scientific rules. 7, simplicity of medication: because of the poor compliance of children with medication, many drugs have obvious toxic side effects, for children should not be too many types of medication, choose the cause of the disease and the main symptoms of the drug at the same time, the available drugs can be used as much as possible, as far as possible to reduce the type of medication. 8, does not affect growth and development: children are in the process of growth and development, all therapeutic drugs to try to avoid the selection of children’s growth and development of adverse effects of drugs, which is an important principle of pediatric medicine. Therefore, there are many drugs that work well in adults, but cannot be used in childhood.