Eardrum perforation, should be treated according to the cause of the disease, generally common causes are purulent otitis media, middle ear cholesteatoma and trauma, etc., to take the treatment includes infection control, surgical treatment, etc., for different causes and conditions should choose different methods, there is no fastest method. 1. Suppurative otitis media perforation: generally available penicillin, cephalosporins and other drugs to fight infection, first 3% hydrogen peroxide solution to thoroughly clean and swab the external auditory canal pus or suction will be suction pus. After controlling the infection, some patients’ perforated eardrums can heal on their own, while most of the patients need to repair the eardrums through surgical treatment. 2. Middle ear cholesteatoma perforation: Surgery should be chosen to completely remove the cholesteatoma and other granulation and inflammatory lesions, and repair the damaged eardrum at the same time or at a later date. 3. Traumatic perforation: Remove foreign bodies, blood clots and pus in the external auditory canal; most small and medium-sized perforations can be healed on their own without infection; if the perforation does not heal, tympanic membrane repair can be carried out on an elective basis. Eardrum perforation may also have other causes, should be timely to the hospital, the doctor according to the symptoms, signs and auxiliary examination to determine the specific cause of the disease, according to the cause of the disease to give the correct medication and treatment.