According to statistics, China is currently the world’s largest obese country, with an obese population of nearly 90 million, obesity has become a major problem and challenge in China, which not only affects the health of obese patients, but also interferes with normal life. Through more than 20 years of experience in weight loss and metabolic surgery, we found that most obese people are not deep enough in the knowledge of “obesity” and take many detours in the process of weight loss, which often leads to the phenomenon of “ineffective weight loss” and “weight loss rebound”. Here, Prof. Wu Liangping calls on everyone to correctly perceive obesity, obtain information through authoritative and professional channels, and use scientific methods to lose weight, so as to improve the quality of life and prolong life expectancy. In the process of weight loss, why does the phenomenon of losing more and more weight occur? This is because everyone’s body has a weight “adjustment point”, short-term weight gain or loss will automatically compensate for the body, the weight tends to return to the level of the adjustment point. Therefore, relying on lifestyle, dietary changes or pharmaceutical interventions will have little effect on the change of the adjustment point. If we rely on dieting alone, it is impossible to reduce the body’s adjustment point, and it will easily lead to the result of “re-fat”. At present, more and more obese patients begin to accept bariatric surgery to treat obesity, and achieve good results in weight loss. The reason is that the bariatric surgery, by changing the structure of the gastrointestinal tract, has induced a positive change in the gastrointestinal hormones, thus lowering the body fat regulating point and ultimately achieving long-term effective weight loss. Since 2013, “bariatric surgery” has been ranked as one of the top 10 medical innovations by the Cleveland Medical Center in the United States, and more and more obese patients are receiving this treatment method and achieving good results in weight loss. There are two main types of bariatric surgery in the world, one is sleeve gastrectomy and the other is gastric bypass. Sleeve gastrectomy is the removal of the greater curvature of the stomach, preserving 100cc of gastric volume, to reduce the secretion of gastric hunger hormone (ghrelin) and significantly reduce hunger to lose weight. The surgery is simpler, safer and has a lower percentage of complications. In contrast, gastric bypass surgery only divides the stomach into two parts, and the re-formed small gastric sac with a volume of about 30 cc is connected to the small intestine bypass to achieve restriction of food intake and reduction of food absorption, while the large stomach remains in the body. In addition to the change in the flow of food after the surgery, the body absorbs less nutrients, and in the case of calories consumed being less than calories consumed, slimming can therefore be achieved. Compared to patients who do not undergo weight loss surgery, the risk of diabetes is greatly reduced after weight loss, and it also effectively relieves the pressure of weight on the bones, thus relieving osteoarthritis, as well as effectively addressing and improving cardiovascular disease. Weight loss surgery is one of the most effective treatment options for polycystic ovary syndrome in combination with obesity. In fact, patients who undergo bariatric surgery experience varying degrees of improvement in overall, emotional, physical, social and energy recovery compared to medication. Weight loss is a long-term and arduous project, we need to understand the body fat adjustment point and reduce weight through scientific weight loss means in order to have a healthy and happy life!