Newborns of mothers with hepatitis B teratitis minor need to be blocked. Guidelines on the prevention of mother-to-child transmission of hepatitis B virus state that newborns of mothers who are hepatitis B surface antigen positive (HBsAg-positive) are recommended to be vaccinated with recombinant yeast hepatitis B vaccine within 12 hours of birth, receive hepatitis B immunoglobulin (HBIG) as soon as possible, and complete the hepatitis B vaccinations at 1 and 6 months of age. It can further reduce the incidence of mother-to-child transmission of the hepatitis B virus. In fact, prevention of mother-to-child transmission should be carried out during pregnancy. Pregnant women who are positive for hepatitis B surface antigen and have hepatitis B virus DNA load ≥2×105IU/ml should receive antiviral therapy starting from 28 weeks of gestation and continuing at least until birth to prevent mother-to-child transmission. So regardless of whether the mother is a major or minor triple positive, blockade is required.