Try not to take sildenafil after drinking alcohol, so as not to induce the emergence of adverse drug reactions, to prevent the emergence of life-threatening. Sildenafil is a type 5 phosphodiesterase inhibitor, clinically mainly used for the treatment of male erectile dysfunction. The mechanism of action of the drug is to improve the cavernous blood congestion of the penis after erection, thus improving the abnormal erectile function and prolonging the ejaculation time. The drug is usually taken about 1-3 hours before intercourse. The drug may have some adverse drug reactions, and common symptoms include conditions such as headache, dizziness, nausea and vomiting, and abdominal discomfort. Among other things, the drug may also cause patients to experience a drop in blood pressure. The patient’s blood vessels dilate after drinking alcohol, which may exacerbate the drop in blood pressure. If the patient has recently used nitrate drugs, the drop in blood pressure is even more obvious, which may lead to life-threatening situations. Therefore, patients try not to take sildenafil after drinking alcohol, must be under the guidance of the doctor, combined with the patient’s specific situation of the correct use of drugs, to ensure the safety of the drug, to prevent the occurrence of adverse drug reactions.