There are many causes of anal opening itching, in the choice of medication must be based on the patient’s specific situation, clear causes, treatment, generally can be applied erythromycin ointment, glucocorticoid ointment, hemorrhoidal ointment and other ointments. 1. Erythromycin ointment: If the patient’s anal opening itching is caused by eczema due to perianal infection, you can use water to clean the itching area first, and then apply erythromycin ointment. 2. Glucocorticoid ointment: If the patient’s anal opening itching and eczema is caused by allergy or imbalance in the regulation of their own hormone levels, they can apply glucocorticoid ointment for treatment, such as hydrocortisone ointment, tretinoin ointment and so on. 3. Hemorrhoid cream: If the anal opening itching is due to anal fissure, hemorrhoids and other causes, you can first use 1:5000 potassium permanganate solution around the anal opening for cleaning, to keep the anal opening clean, and then apply hemorrhoidal ointment, such as Ma Yinglong hemorrhoidal ointment, anus tai ointment and other medicines for treatment. The reason for the itchy anal opening, there may be other factors, it is recommended that you should go to the hospital in time for examination, a clear diagnosis, accept the professional doctor’s reasonable standardized treatment, it is not recommended to blindly use their own medication, so as not to cause adverse drug reactions or aggravate the condition.