Kawasaki disease is not a hereditary disease, but has a certain genetic predisposition, affected by family factors, patients have a certain family susceptibility, after being infected by the pathogen, activate the body’s immune system mechanism, resulting in the occurrence of the disease. The specific cause of Kawasaki disease is not clear, from a statistical point of view, the occurrence of the disease is closely related to geographical factors and family factors; after being infected by the pathogen, the patient stimulates the body’s immune system mechanism, resulting in systemic multi-system damage, and the onset of the disease itself shows family aggregation, and it is currently believed that the disease has a certain hereditary predisposition. Kawasaki disease itself has a certain genetic susceptibility, we should pay attention to the emergence of related symptoms, consider the possibility of the disease, under the guidance of the clinician for timely treatment, to prevent irreversible damage.