What are the main extra-pulmonary symptoms of lung cancer? 1.Bone and joint symptoms: such symptoms are more common. Because lung cancer cells can produce certain special endocrine hormones (heterogenous hormones), antigens and enzymes, these substances can operate on bone and joint parts, resulting in swelling and pain of bone and joint, often involving tibia, fibula, ulna, radius and other bones and joints, and the ends of fingers and toes are often expanded to pestle-like fingers. 2.Shoulder and back pain: Lung cancer of peripheral lung type often develops posteriorly and erodes the pleura, involving the ribs and chest wall tissues, thus causing shoulder and back pain. 3.Heartiness: lung cancer metastases compress the laryngeal nerve, which may paralyze the vocal cords and cause hoarseness. 4.Neurological symptoms: brain metastasis of lung cancer may cause headache, vomiting, sudden coma, aphasia, hemiparesis and other neurological symptoms, which are often misdiagnosed as and thrombosis or brain tumor due to the lack of obvious lung symptoms. 5. Male breast enlargement: about 10%-20% of male lung cancer patients have breast enlargement, unilateral but mostly bilateral, and this symptom appears about one year earlier than pulmonary symptoms such as cough, blood in sputum, chest pain and shortness of breath. This is because certain lung cancer cells can secrete chorionic gonadotropin, a hormone that can cause hyperplasia of breast tissue and make the breast hypertrophy.