It is possible to have a successful birth with a first-trimester fetal arrest because of chromosome 45xo. Chromosomal abnormalities of the embryo are high in most of the causes of fetal arrest and are a common factor in fetal arrest.45xo is a type of chromosomal abnormality. Chromosomal abnormalities are mostly incidental. A fetus with chromosomal abnormalities found in one fetus needs to be screened for chromosomal conditions in both spouses. When both partners do not have any chromosomal abnormality, the cause of chromosome 45xo in the embryo may be due to an error in meiosis during the formation of the egg or sperm, and most couples can have a normal pregnancy in the next pregnancy. Couples need to undergo a complete and detailed reproductive function test before preparing for pregnancy, and keep a good mindset and don’t be overly nervous.