Stay up late for a long time on the body has some damage, such as neurasthenia, reduced immunity, there may also be gastrointestinal disorders. But if for some reason you need to go to bed late and sleep enough time, long-term so that the formation of regular, not much effect on the body. 1. Staying up late will cause the next day’s mental instability, can not concentrate on work and study, long-term stay up late will lead to insomnia, severe neurasthenia. 2. Long-term stay up late may cause gastrointestinal dysfunction, appetite, acid reflux, etc., serious cholecystitis. 3. Long-term stay up late will reduce the body’s immunity, easy to appear upper respiratory tract infections, herpes zoster and so on. 4. Long-term staying up late causes disruption of the body’s biological clock, there may be endocrine disorders, resulting in dull, rough skin, but also lead to skin laxity, pigmentation and so on. But if the regular work and rest, even if you sleep late, but enough sleep, stay up late will not necessarily bring damage, but should try to avoid staying up late, it is recommended to go to bed early and get up early.