Biological vaccine therapy is useful in the treatment of cirrhosis decompensation, but the therapeutic effect may be different due to the big difference of individuals. Biological immune repair therapy is a new method of cirrhosis treatment, which is to regulate immune factors with the help of molecular biology technology, through carotid intervention, intrathecal intervention, intravenous delivery, etc. It is able to comprehensively remove cirrhosis virus, and then repair senescent and damaged immune cells, and improve the immunity of patients. It is generally not easy to relapse after treatment, and the efficacy is relatively high. Biological immunotherapy can realize individualized treatment, not easy to relapse after treatment, and the efficacy is relatively high, long duration, with targeted action of the immune killing reaction, non-toxic to the normal cells of the human body, therefore, cirrhosis patients with decompensated liver can choose the biological vaccine therapy treatment according to their own actual situation, under the advice of the doctor. However, bio-immunotherapy treatment is not suitable for patients with weak constitution, organ transplantation, presence of autoimmune diseases and infectious diseases, as well as pregnant and lactating women and HIV-infected patients. Cirrhosis patients should consult the hospital in time and choose bioimmunotherapy treatment according to their own conditions under the doctor’s advice.