Acne, also known as pimples, acne, etc., is one of the most common diseases in dermatology, with a fairly high incidence, and more than 80% of patients may have suffered from it. It is a chronic skin disease of the sebaceous glands of the hair follicles, which eventually manifests as follicle blockage and can develop into inflammatory papules, pustules, nodules, cysts, formation of pigmentation marks, enlarged pores, and even scars and other skin damage.
Proper control of acne development thus prevents serious side effects such as scarring of lesions in some patients. There are many acne treatment options, such as conventional medications (retinoids, antibiotics, etc.), fruit acids, lasers (IPL, PDL, etc.), physical therapy (needle picking, hormone injections, etc.) and photodynamic therapy. Photodynamic therapy is a new treatment method for patients with moderate to severe acne.
Photodynamic therapy (PDT), also known as light irradiation therapy or photochemotherapy, is a new technology that uses photodynamic reactions for disease diagnosis and treatment based on the interaction of light, photosensitizers and oxygen. The physical therapy of acne. Photodynamic therapy treatment requires the following three elements: first, a photosensitizer, i.e., the photodynamic therapy drug 5-amino-4-ketovaleric acid hydrochloride (5-ALA); second, molecular oxygen; and third, a light source, i.e., a 633nm red LED light source. The PDT treatment of acne is aimed at the four major causes of acne and works in multiple ways. .
Now the recommended treatment plan is: 5% ALA red light photodynamic three times treatment plan. The operation process of photodynamic treatment of acne can be simply divided into the following steps: drug preparation, drug application, package sealing and light exposure.
1. Drug preparation: 5% 5-ALA.
2. Light source and wavelength: LED photodynamic therapy instrument Red light 633nm±10nm.
3.Sealing time: 1-1.5h.
4, illumination time: 20min.
5.Lighting dose (energy density): 72-126J/cm2.
6.Lighting distance: 10-15cm.
7, the course of treatment and the number of treatment: 3 times the treatment for a course of treatment.
8, treatment interval: the recommended treatment interval is 7-14 days, at most should not exceed 4 weeks.
Indications.
1. Cases of acne that are ineffective with traditional treatment methods, or cannot be controlled.
2.Acne cases in which antibiotic treatment is not appropriate.
3. Acne cases that cannot tolerate the stimulation of topical medications.
4, more severe cases of acne.
5, acne cases with liver or kidney function impairment.
6.Severe acne cases that are prone to scar formation causing cosmetic problems.
Contraindications.
1, patients with skin light allergy to the wavelength range around 632.8 nm.
2.Persons with porphyria or known allergy to porphyrins.
3, Patients with known hypersensitivity to any component of topical aminoketovaleric acid hydrochloride solution.
4, pregnant and lactating women.
5, those taking photosensitizing drugs.
6, patients with photosensitive diseases, such as SLE, chronic photosensitive dermatitis, etc.
Some treatment reactions may occur during photodynamic therapy, such as slight stinging during the process of light exposure, local erythema and swelling, and transient acne aggravation, and a very small number of patients may experience pigmentation and dry skin.