Pancreatic cancer is an insidious, extremely dangerous and highly malignant tumor of the digestive tract. In particular, the symptoms of pancreatic tail cancer are often more insidious, the mass is larger when detected, and distant metastasis is likely to have occurred, and its prognosis is less than that of pancreatic head cancer. In the United States, pancreatic cancer ranks as the fourth most common malignant tumor death. In China, pancreatic cancer has become one of the top ten malignant tumors that kill the population. With the improvement of people’s living standard and the change of diet structure and living habits, the incidence of pancreatic cancer in China is increasing year by year. In recent years, the overall incidence of malignant tumors in Shanghai has been decreasing, but the incidence of pancreatic cancer has been increasing significantly, ranking eighth in the city in terms of malignant tumors and sixth in terms of mortality. The diagnosis of pancreatic cancer mainly relies on clinical manifestations and imaging. Early discomfort in the upper abdomen due to increased pressure in the lumen caused by pancreatic duct obstruction is a common first symptom of pancreatic cancer, but due to its non-specific nature, it is often easily mistaken for a gastrointestinal disease. Since most of the patients are middle-aged and elderly, some of them, like Mr. Wang, usually have a lot of social functions, can easily be treated as chronic gastritis, and because chronic gastritis has a prolonged course and is prone to recurrence, there are few patients who consider pancreatic cancer only when symptoms such as jaundice, emaciation and back pain appear. Therefore, clinically, when the above-mentioned conditions occur, one should be alert and consider whether they are caused by pancreatic cancer. People who suspect pancreatic cancer and those who are at high risk of pancreatic cancer should prefer non-invasive tests for screening, such as ultrasound, CT and serological tumor markers. Combined testing of tumor markers and combined with imaging findings can improve the positive rate and help in the diagnosis and differential diagnosis of pancreatic cancer. The main methods of pancreatic cancer treatment include surgery, chemotherapy, radiotherapy and biotherapy. Radical surgery is still the only effective cure for pancreatic cancer, but it is complicated, traumatic and has a high complication rate. Currently, individualized treatment and multidisciplinary comprehensive treatment are implemented clinically, which can improve the treatment effect and long-term survival rate of pancreatic cancer.