IgA nephropathy grade II is usually not particularly serious. IgA Nephropathy is a chronic glomerulonephritis caused by abnormal deposition of immunoglobulin A in the glomerular plasma membrane area, which is pathologically characterized by plasma membrane hyperplasia and deposition of IgA-based immune complexes in the plasma membrane area. IgA nephropathy is generally graded by Richter’s classification, which is mainly divided into five grades, and the higher the grade, the more serious it is. IgA nephropathy grade II manifests itself as a glomerulus presenting focal proliferation and sclerosis of the thylakoid membranes (<50%), with rare small crescents, no damage to the tubules and interstitial spaces of the kidneys, and focal damage under light microscopy, with the lesion affecting a small number of glomeruli (foci) and some of the lobules of the glomeruli (segments). Clinical symptoms in this stage are mostly proteinuria, hematuria and other phenomena, and the chances of renal insufficiency and hypertension are small, so they are usually not particularly serious. It is recommended that patients with IgA nephropathy should go to the hospital in time and follow the doctor’s instructions for standardized diagnosis and treatment in order to avoid adverse effects.