Pancreatic fistula is treated with medication and surgery, and you can recover as soon as possible through these two methods under the guidance of your doctor. 1. Drug treatment: commonly used drugs include antibiotics, drugs to inhibit pancreatic exocrine secretion, drugs to inhibit pancreatic enzyme activity, nutritional support drugs and so on. (1) Antibiotics: for example, ceftazidime, etimicin, etc. A variety of antibiotics will be used in combination for infection control. (2) Inhibition of pancreatic exocrine drugs: such as gastric inhibitory peptide, growth inhibitors, etc., used to inhibit pancreatic secretions, relax the smooth muscle of the intestine, reduce the occurrence of pancreatic fistula and promote its healing. (3) Inhibition of pancreatic enzyme activity drugs: such as gabexate, etc., used to reduce the corrosion of pancreatic fluid on the surrounding tissues and anastomosis. (4) Nutritional support drugs: such as potassium chloride, etc., used to improve the patient’s resistance. 2. Surgical treatment: commonly used surgical methods include pancreatic fistula sinus tract resection, pancreatic fistula puncture and so on. (1) Pancreatic fistula sinus tract resection: to close the fistula tract, prevent recurrence, and promote its recovery. (2) Pancreatic fistula puncture: drain out the pancreatic fluid and alleviate the patient’s symptoms. If pancreatic fistula occurs, it is recommended to actively treat it under the guidance of the doctor and follow the doctor’s instructions for medication.