If the toothache symptoms are caused by inflammatory diseases of the oral cavity, they will usually be gradually relieved after 1-2 days of taking metronidazole. Metronidazole is a common antibacterial antibiotic that is commonly used clinically to treat inflammatory lesions caused by bacterial infections of the reproductive, respiratory, and oral systems. Metronidazole, as a nitroimidazole drug, can eliminate inflammation (mainly anaerobic bacteria) by destroying the DNA of microbial cells and inhibiting nucleic acid synthesis, and has a therapeutic effect on the performance of toothache symptoms caused by oral inflammatory diseases, which can be seen in about 1-2 days after the drug is used. The treatment effect may be even better if it is combined with analgesic and antispasmodic drugs such as acetaminophen tablets and rhizome suplementary granules under the guidance of a doctor. However, it should be noted that metronidazole generally has no significant therapeutic effect on toothache symptoms caused by non-inflammatory diseases, such as tooth decay, tooth sensitivity, food impaction, etc. During the period of taking metronidazole, drinking alcohol or eating food containing alcohol should be prohibited to avoid causing disulfiram reaction and adverse symptomatic reactions such as nausea and vomiting, shortness of breath and tachycardia.