Dry mouth and generalized weakness may be due to lack of rest, colds, diabetes, dry syndrome, etc., and need to be treated for the cause. 1. Lack of rest: long time labor, lack of rest, living environment is too dry and other factors lead to the body lack of water, so this symptom occurs. You need to drink more water and pay attention to rest. 2. Colds: viral infection as an exogenous thermogenic source, stimulating the body temperature rise, leading to water evaporation in the mouth and dry mouth, and by inducing a systemic immune response and lead to general weakness. Need to take non-steroidal anti-inflammatory drugs such as ibuprofen, aspirin, etc. Influenza requires the use of ribavirin, tenofovir and other antiviral drugs treatment. 3. Diabetes mellitus: diabetic patients due to osmotic diuresis, a large amount of water loss through the urine and dry mouth and thirst, due to glucose utilization disorders appearing energy supply and general weakness. It can be treated by taking hypoglycemic drugs such as metformin, rosiglitazone, glipizide, saxagliptin, etc., or subcutaneous injection of insulin, together with dietary control and exercise therapy. 4. Dry syndrome: autoimmune system targeting salivary glands attack, resulting in salivary synthesis and secretion disorders, so the mouth will be dry and thirsty, accompanied by generalized weakness, low fever and other symptoms. Artificial saliva, hydroxychloroquine, prednisone, methotrexate, hairy fruit rutabaga alkaloids and other drugs can be used to treat. If the symptoms of dry mouth and thirst and generalized weakness do not improve for a long time, you should seek early medical treatment to clarify the diagnosis, follow the doctor’s instructions for systematic treatment, and avoid unauthorized use of drugs.