Colonic villous adenomas with high-grade epithelial sarcomatoid lesions are usually fine after removal. However, it is not possible to generalize. Colonic villous adenoma high-grade epithelial sarcomatoid lesion is usually still in the range of pre-cancerous lesions, and the aggressive use of surgical resection can make the condition better, and generally can achieve clinical cure. Suffering from colonic choriocapillaris adenoma high-grade epithelial sarcomatoid changes can usually choose endoscopic minimally invasive surgical resection for treatment, with this method of surgery, less traumatic, recovery is relatively fast, suitable for patients with localized mucosal stripping. You can also choose surgical resection, resection at the time of treatment, more clean, suitable for patients with serious conditions requiring intestinal resection. However, some patients may not be able to be completely cured by surgery due to lesions invading the surrounding tissues and involving lesions, etc., and further other treatments are needed. Colonic villous adenoma high-grade epithelial sarcomatoid changes should be timely to the hospital, choose the appropriate treatment, so as not to delay the condition.