Anti-perinuclear factor is an antibody specific for rheumatoid arthritis, and a positive level of this antibody is very meaningful for the diagnosis of rheumatoid arthritis. Rheumatoid arthritis can be diagnosed if the patient also has swelling and pain in small joints such as the hand joints. Patients who are also positive for anti perinuclear factor antibodies should have further antibodies related to other rheumatoid arthritis such as rheumatoid factor and anti-cyclic citrulline antibodies. With early diagnosis of rheumatoid arthritis as well as systematic treatment, most of the disease will be well controlled. There are many drugs available for the treatment of this disease, so patients must go to a regular hospital rheumatology department for systematic examination as well as standardized treatment, and must not believe in the so-called prescriptions and delay the disease.