The application of pediatric antipyretics should pay attention to the following matters: 1, the pediatric thermoregulatory center is not perfect, so pediatric antipyretics should be based on physical cooling. 2, fever is a manifestation of the body’s resistance to disease, should actively find the cause of the disease, treatment of the primary disease. 3.Master the active ingredients, drug action characteristics, adverse reactions, contraindications, and contraindications of various antipyretic and analgesic drugs to prevent damage to the body due to improper use of drugs. 4.According to the characteristics of pediatric antipyretic drugs, reasonable control of the use interval of pediatric antipyretic drugs. 5, should be taken on time and in accordance with the dose, do not arbitrarily increase the dose or shorten the dosing interval. 6.During the period of antipyretic, the child should be advised to drink more water to avoid deficiency due to profuse sweating. 7.Usually choose one kind of antipyretic drug, and consider the combination when the efficacy is really not satisfactory. Check the body temperature about one hour after each dose to judge the effect of antipyretic. 8.Reasonable control of the use of the course of treatment, the fever is stopped. 9.Toxic side effects of drugs should be noted during the use of drugs, such as blood changes, gastrointestinal reactions, liver and kidney function damage, etc. 10, severe, high fever persistently children can be used when necessary, sub-hibernation therapy.