Taking aspirin, platelet count less than 50 x 10^9/L can no longer be used. Platelets have the role of maintaining the integrity of the blood vessel wall, is an important component of the body to play the function of coagulation and hemostasis, and aspirin is a non-steroidal anti-inflammatory drugs, analgesic, anti-inflammatory, inhibit the role of platelet aggregation, clinically aspirin is commonly used in the prevention of thrombosis. Platelet count less than 50 × 10^9 / L, belongs to the moderate to severe thrombocytopenia, the body can appear skin, mucous membrane bleeding and other symptoms, and bleeding is not easy to stop bleeding, severe hemorrhagic shock. Therefore, in order to avoid aggravating the symptoms of thrombocytopenia and to prevent adverse conditions such as difficulty in stopping bleeding after bleeding, usually when the platelet count is lower than 50×10^9/L, the use of aspirin should be prohibited. When taking aspirin, blood counts should be closely monitored to observe changes in platelets to avoid adverse effects. Common adverse reactions include thrombocytopenia, diarrhea, fever, etc. This drug is contraindicated in patients with severe hepatic and renal impairment and in patients who are allergic to the product. Specific drug use should be under the guidance of a physician.