Separation of finger cap and flesh may be caused by ringworm of the nail, perinail warts, psoriasis and other diseases, which need to be treated with medication, physical therapy and surgery according to the cause. 1. Nail fungus: common symptoms include nail separation, thickening, shedding, etc., which can be manifested as the separation of finger caps and flesh. Patients need to follow the doctor’s instructions to use topical anti-fungal drugs such as terbinafine tincture and amorolfine application. Patients with severe symptoms need to take oral itraconazole, terbinafine and other antifungal drugs as prescribed by the doctor. For those who have severe warts, it is necessary to consider performing nail removal or nail extraction. 2. Periungual warts: some patients may have symptoms such as separation of the finger cap from the flesh and hyperkeratosis under the nail. Patients can follow the doctor’s instructions to use topical salicylic acid cream, 5% imiquimod and other drugs. Physical methods such as liquid nitrogen freezing and laser therapy are also required. If large perinail warts are present, combined electrodrying scraping or surgical excision is required. 3. Psoriasis: patients will have the symptoms of nail separation and nail depression, so some patients have the situation of finger cover and flesh separation. Patients need to follow the doctor’s prescription of topical glucocorticosteroids such as dexamethasone and hydrocortisone, vitamin D3 analogs such as calprotectin and tacalcitol, and calcium-modulated neural phosphatase inhibitors such as tacrolimus and pimecrolimus. In some patients, vitamin A analogs such as avobenzone and avitamin A, as well as immunosuppressants such as methotrexate and cyclophosphamide, are used as prescribed by the physician. Commonly used physiotherapeutic measures include excimer laser and UVB phototherapy. There are more reasons for the separation of the finger cap from the flesh, so it is necessary to go to the hospital and cooperate with the doctor to treat the original disease.