What causes nephrogenic edema?

In patients with nephrotic syndrome, due to glomerular disease, their original barrier effect is impaired and a large amount of protein is filtered out of the blood and into the urine.
This in turn leads to low plasma protein and decreased plasma colloid osmotic pressure. Fluid infiltration from capillaries into the tissue interstitial space increases, and edema results from reduced reabsorption. At the same time, the decrease in effective blood volume stimulates an increase in renin-angiotensin-aldosterone activity (an important hormone regulating water and sodium metabolism) and an increase in antidiuretic hormone secretion to further aggravate edema. Edema mostly starts from the lower extremities.
Prompt consultation with the nephrology department is required, and reasonable treatment should be provided under the guidance of the doctor.

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