Some women have acne related to their menstrual cycle, manifesting as acne growth or aggravation in the premenstrual period, mainly on the forehead, between the eyebrows or on one cheek. This is mainly related to the high androgen level in the premenstrual period leading to increased sebaceous gland activity and increased secretion of sebum. The excessive secretion of sebum provides nutrients for Propionibacterium acnes, and the reproduction of infection by Propionibacterium acnes leads to hyperkeratosis of the follicle sebaceous gland opening and the formation of acne.
At the same time, Propionibacterium acnes produces substances that promote different degrees of inflammatory reactions around the hair follicles, leading to the appearance of pimples or even cystic acne.
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