Why patients with brain metastases have a short survival time

On the one hand, the occurrence of brain metastasis means that the tumor cells in the primary lesion have spread and may metastasize to multiple parts of the body at the same time, and patients are likely to develop systemic tumor complications, including neurological symptoms. On the other hand, the tumor grows expansively in the skull, and the growth process will compress the brain tissue and block the cerebrospinal fluid circulation pathway, thus causing intracranial hypertension symptoms, such as headache, nausea and vomiting.
If the tumor continues to progress, the brain tissues will be displaced by the pressure, and symptoms such as impaired limb movement or impaired consciousness will occur. After brain metastasis occurs, the effect of drug treatment is poor. There is blood-brain barrier in brain tissue, so it is not easy for general chemotherapy drugs to enter the brain.

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