Pearl rash generally refers to pearly penile papules, which cannot be eliminated with the use of medications. Pearly penile papules may be related to local irritation, abnormal physiological development and other factors, manifested as pearly papules on the coronal edge of the penis and the coronal sulcus. Pearl rash using drugs can not remove the skin lesions, when there is inflammation can use drugs to relieve, such as redness, itching, you can use a certain concentration of the proportion of the Jeerin liquid to soak the affected area; if there is oozing, you can use Lefenur liquid wet compresses on the affected area; local secondary bacterial infections, antibiotic ointment can be used, such as mupirocin ointment to smear the affected area. All of the above drugs have adverse reactions, it is recommended to use under the guidance of a doctor. Pearl rashes are generally removed by physical therapy, such as cryotherapy, high-frequency electrosurgery, laser therapy, etc. It is recommended that patients go to the dermatology department of regular hospitals for treatment.