Chest pain, chest tightness, shortness of breath, cold hands and feet, the causes include coronary heart disease, hemorrhagic shock, heart failure, mitral stenosis and so on. 1. Coronary heart disease: If various factors lead to the narrowing of coronary arteries, myocardial ischemia and necrosis can occur at this time, resulting in chest pain, chest tightness and shortness of breath, and due to the lack of cardiac output resulting in ischemia of the extremities, so there is the phenomenon of cold hands and feet. 2. Hemorrhagic shock: when various factors lead to hemorrhagic shock, myocardial ischemia and necrosis, chest pain and chest tightness, and cold extremities due to insufficient blood supply to the extremities. 3. Heart failure: if various factors lead to heart failure, heart function decline, at this time there can be chest pain chest tightness shortness of breath cold hands and feet phenomenon. 4. Mitral valve stenosis: due to the narrowing of the mitral valve, the heart pumps less blood, coronary ischemia triggers chest tightness and chest pain, limb ischemia leads to cold limbs. Chest pain, chest tightness, shortness of breath, cold hands and feet phenomenon, please consult a doctor in a timely manner, in accordance with the doctor’s instructions reasonable treatment.