High total bilirubin may be due to liver disease, hemolytic disease, biliary obstruction, etc., and should be treated according to the cause of the disease, for example, liver disease should be treated according to the cause of liver damage by liver preservation; hemolytic disease should be treated by glucocorticosteroids, etc.; biliary obstruction should be treated by surgery, etc.. Whether the total bilirubin can be normalized depends on the condition and individual differences. 1. Liver diseases: viral hepatitis, alcoholic liver injury, drug liver injury, cirrhosis and other liver diseases may cause high total bilirubin, and should apply liver-protecting drugs such as bicyclic alcohol, glutathione, etc., and should be treated according to the cause of liver injury, such as applying entecavir for viral hepatitis B, and abstaining from alcohol for alcoholic liver disease. 2. Hemolytic disease: autoimmune hemolytic anemia can lead to high total bilirubin and should be treated with glucocorticoids and immunosuppressants. 3. Bile duct obstruction: bile duct stone, bile duct cancer, pancreatic head cancer and other bile duct obstruction can also cause high total bilirubin, and often need surgical treatment. If you have high total bilirubin, you should go to the hospital for consultation and treatment under the guidance of the doctor.