Chest tightness and shortness of breath during menopause may be caused by perimenopausal syndrome, asthma, viral myocarditis and other diseases, which need to be treated by general measures, medication, surgery, etc. for the cause of the disease, and some of them need no treatment for mild symptoms. 1. Perimenopausal syndrome: patients need to reduce their own stress, maintain a happy mood and increase social activities. Patients can take vitamin B12, glutamine and other nerve-nourishing drugs as prescribed by the doctor, and those with obvious symptoms need to use estrogenic drugs such as estradiol valerate and 17β-estradiol or progestational drugs such as micronized progesterone and dydrogesterone, as well as antidepressants such as paroxetine and fluoxetine as prescribed by the doctor. In addition, since menopause is a natural physiological stage, some mild symptoms do not require treatment and can be relieved on their own. 2. Asthma: Patients need to pay attention to keep warm, avoid getting cold, and also need to ensure that they have enough rest time. Patients need to use glucocorticoid drugs such as budesonide and dexamethasone as prescribed by the doctor, and some patients also need to use β2 agonists such as salbutamol and terbutaline as prescribed by the doctor, as well as anticholinergic drugs such as ipratropium bromide and tiotropium bromide. 3. Viral myocarditis: patients need bed rest, reduce the heart load, easy to digest and rich in vitamins and proteins. Patients should follow the doctor’s instructions to use interferon and other antiviral drugs, as well as adenosine triphosphate, cyclic adenosine cyclophosphate and other drugs to promote myocardial metabolism. To summarize, menopausal patients need to strengthen their daily life management, and if any discomfort occurs, they should go to the hospital for consultation and treatment according to the doctor’s prescription.