The main form of treatment for premature ejaculation is not medication, but treatment of the causative agent according to its cause. The disease is usually treated by treating the psychological causes of the patient. Medication is only an adjunctive treatment, including the use of 5-hydroxytryptamine reuptake inhibitors. 1. To treat the psychological causes of the disease, we can use sensual concentration training method and work closely with the patient’s wife to overcome the patient’s misperception of the behavior and the sense of self-guilt, so as to establish and restore the patient’s natural response. 2. Use 5-hydroxytryptamine reuptake inhibitor representative drugs, such as dapoxetine, paroxetine, etc. Such drugs can prolong the concentration of 5-hydroxytryptamine in the central system, thus prolonging the ejaculation time. Contraindications include recent strokes, heart disease, low blood pressure, and severe kidney damage. Once the premature ejaculation, can not blindly take drugs, should go to the hospital in time, under the correct guidance of the doctor to follow the doctor’s instructions standardized treatment.