Wrinkles are small fine lines that form when a variety of factors, including free radicals, destroy collagen, active substances, and oxidized cells within normal cell membrane tissue. Patients with many wrinkles can remove them through general treatment, injection treatment, physical therapy and surgery. 1. General treatment: patients with many wrinkles should pay attention to hydration and moisturizing in daily life and sun protection. In addition, patients should pay attention to diet and rest to avoid aggravation due to fatigue. 2. Injection treatment: patients can be injected with botulinum toxin under the guidance of doctors, which can inhibit the release of acetylcholine from neuromuscular junction, thus achieving the effect of removing wrinkles. In addition, hyaluronic acid can also be injected locally to fill in the folds of the skin, thus relieving the symptoms. 3. Physical therapy: Patients can undergo laser treatment under the guidance of a doctor. Short pulsed light beams are directed to the irregular skin, which can stimulate collagen growth and skin thickening, thus reducing the effect of wrinkles. 4. Surgery: If the above methods are not effective, surgery can also be used, which is currently commonly used to remove wrinkles by thread sculpture. It should be noted that patients who have the need for wrinkle reduction should go to the hospital in time and under the guidance of the doctor for regular treatment.