Chest tightness lying down after lobectomy is usually caused by emphysema, pleural effusion, postoperative stress reaction, etc., which can usually be treated with medication under the guidance of the doctor. 1. Emphysema: Emphysema is caused by decreased elasticity of bronchial terminal airways, expansion, and increased lung volume. If the patient has emphysema himself, it may be aggravated after lung surgery. Patients may have symptoms such as fatigue, weight loss, loss of appetite, chest tightness, etc. Patients can use drugs such as aminobromine hydrochloride and ammonium chloride under the guidance of the doctor for treatment, and this drug is prohibited for those with abnormal liver and kidney functions. 2. Pleural effusion: pleural effusion is a kind of symptom manifested by the collection of fluid in the pleural cavity, patients may have low fever, fatigue, chest tightness and other symptoms, patients can use aminobromine hydrochloride and other drugs under the guidance of the doctor for treatment, after the use of the facial swelling, nausea, stomach pain and other symptoms, allergic to aminobromine hydrochloride, prohibited for people with allergies to the drug. 3. Postoperative stress reaction: after lobectomy, after the anesthetic effect, patients may also feel chest tightness, or even chest pain discomfort, need to be observed, the use of pain medication as well as anti-inflammatory drugs, such as celecoxib, cefuroxime and so on. The medication is administered with attention to adverse drug reactions and precautions and contraindications. Patients should go to the hospital and be treated under the supervision of a doctor.