Chest tightness and breathlessness is considered to be related to coronary heart disease, chronic obstructive pulmonary disease, chronic bronchitis, etc. Depending on the condition, it may not be able to relieve quickly, and needs to be combined with the cause of general treatment, drug therapy, surgical treatment, etc.. 1. Coronary heart disease: i.e. coronary atherosclerotic heart disease, often showing chest pain, chest tightness, etc. It is recommended to give antiplatelet therapy such as aspirin, indobufen, tegretol, etc., and to give anti-myocardial ischemic drugs such as nitroglycerin, metoprolol, etc., and to consider surgical treatment for the patients who have unsatisfactory therapeutic effect or serious condition. 2. Chronic obstructive pulmonary disease (COPD): COPD often manifests cough, sputum, shortness of breath, chest tightness, etc. It is recommended to give oxygen therapy or mechanical ventilation, bronchodilators such as salbutamol, terbutaline, glucocorticosteroids, expectorants such as carboxymethylstilbestrol, aminoglutethimide hydrochloride, etc., antibiotics such as azithromycin and erythromycin. 3. Chronic bronchitis: often show cough, cough sputum, wheezing shortness of breath, chest tightness, etc., it is recommended to give the control of infection treatment levofloxacin, amoxicillin, etc., cough expectorant drugs such as compound licorice combination, dextromethorphan, etc., asthma medications such as theophylline class of drugs. Therefore, to relieve the symptoms of chest tightness and breathlessness need to be combined with the cause, in accordance with the doctor’s instructions targeted treatment, to avoid unauthorized abuse of drugs.