Lower eyelid throbbing for a month and then turn to face and mouth, consider that it may be facial muscle spasm, mainly due to ectopic excitation or pseudo-synaptic conduction of the facial nerve. Facial muscle spasm is mostly recurrent, paroxysmal involuntary twitching of the facial muscles on one side. Inflammation and other factors can affect the motor nucleus of the facial nerve and produce focal epileptiform discharges; compression of the facial nerve by an acoustic neuroma or abnormal stimulation can also cause facial muscle spasm. In addition, facial muscle spasms are intermittent in mild cases, and distraction can control spasmodic episodes; in severe cases, frequent episodes are not controlled by consciousness. When there are facial and mouth twitching after persistent fluttering of eyelids, it is recommended to seek medical treatment in time, improve the examination of cranial CT, MRI, etc., to clarify the cause of the disease, and then treat the cause of the disease in a timely manner.