Relief measures for chest tightness and shortness of breath in chronic obstructive pulmonary disease include treatment with oxygen, bronchodilators, cough expectorants, and glucocorticoids. Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow obstruction, often accompanied by wheezing, shortness of breath, chest tightness, dyspnea and other symptoms, which may be aggravated by activity. It is recommended that low-flow oxygen inhalation may improve chest tightness and shortness of breath, while actively using bronchodilators to avoid further spasm of the bronchial tubes and to improve airway resistance, commonly used drugs include salbutamol, ipratropium bromide and so on. Glucocorticosteroids, such as budesonide and fluticasone propionate, can also be used to relieve symptoms. When more sputum is not easily discharged, the bronchial tubes are also usually blocked, leading to insufficient ventilation and chest tightness and shortness of breath, and aminoglutethimide, acetylcysteine, etc. are often used. Acute exacerbation can be appropriately treated with additional antibiotics when there is a clear indication of bacterial infection. Patients with chronic obstructive pulmonary disease who have chest tightness and shortness of breath are advised to consult a doctor in time to avoid delays in their condition. The above drugs should be used under the guidance of a physician.