High blood pressure at the age of 50 can cause damage to target organs such as the heart, kidneys, brain and retina. 1. Heart: long-term high blood pressure can cause right ventricular hypertrophy and dilatation, causing hypertensive heart disease. Hypertensive heart disease is often combined with coronary atherosclerosis and microangiopathy. 2. Kidney: Long-term persistent high blood pressure can lead to ischemia of the renal parenchyma and decreasing number of renal units, eventually causing chronic renal failure. 3. Brain: long-term high blood pressure can cause ischemia and degeneration of cerebral blood vessels, forming micro-aneurysms, and cerebral hemorrhage once the aneurysms rupture. Long-term high blood pressure can cause cerebral atherosclerosis and cerebral thrombosis. 4. Retina: It can cause early spasm of small retinal arteries, and sclerosis can occur with the progress of the disease. If blood pressure rises sharply, it can also cause retinal exudation and hemorrhage. High blood pressure at the age of 50, it is recommended to control blood pressure under the guidance of a doctor to avoid serious complications.