After taking wrinkle injections and finding that the wrinkles are getting worse, the causes are different at different times, and the corresponding treatments are also different. Botulinum toxin injection is used to inhibit the contraction of expression muscles and improve dynamic wrinkles. 1. Botulinum toxin injection only improves dynamic wrinkles. If wrinkles reappear 5-6 months after the injection, patients will have a visual psychological gap and feel that the wrinkles are heavier than before. At this time, the effect can be maintained by injecting Botox again. 2. Ageing and skin relaxation obviously lead to the appearance of static wrinkles, which can be improved by hyaluronic acid filling, autologous fat filling and facial wrinkle removal. In addition, we should pay attention to usually do not do too much facial expression, in the diet do not eat spicy stimulation greasy food, must ensure sufficient sleep, avoid staying up late.