Vulvar squamous epithelial verrucous hyperplasia is considered to be a sexually transmitted disease caused by human papillomavirus (HPV) with warty lesions as the main mode of transmission. Patients who develop vulvar squamous epithelial verrucous hyperplasia should seek prompt medical attention. Vulvar squamous epithelial warty hyperplasia is mainly manifested as skin and mucous membrane superfluous organisms, the size and shape of which often change, and can occur in the external genitalia and anus and other parts. In severe cases, the woman’s vagina may develop an abnormal discharge with an unpleasant odor. When these conditions are detected, one should not engage in sexual intercourse again until a doctor’s appointment is made. Most patients with vulvar squamous epithelial verrucous hyperplasia will see improvement in their skin after treatment. It should be noted that warts are prone to recurrence, but if they do not recur within 6 months of treatment, the likelihood of recurrence is generally considered to be greatly reduced. It is recommended that patients follow the treatment as prescribed by their doctor.