Headache, orbital pain, nausea and vomiting need to be considered for the following common diseases: 1. migraine, which is a kind of vascular neurological headache, easily accompanied by orbital pain when the frontal and temporal areas are involved, and easy to have autonomic reactions such as nausea and vomiting. 2. cluster headache, more common in men, with headache attacks in bunches, easily appearing at night, with orbital pain, accompanied by conjunctival congestion and edema. 3. intracranial Organic lesions, such as brain tumors and cerebral hemorrhage involving the frontotemporal lobe, often have these symptoms. 4. Glaucoma, especially acute closed-angle glaucoma, can cause eye pain and headache if there is a significant increase in intraocular pressure. 5. Painful ocular muscle palsy, a non-specific inflammation of the cavernous sinus in the skull, has the above symptoms along with the symptoms of oculomotor nerve palsy. It manifests as drooping eyelids, dilated pupils, and loss of light reflex.