Headache, nausea, malaise and weakness are mainly seen in several aspects of cold, intracranial infection and cerebral hemorrhage, as follows: 1. Cold: patients with headache, nausea and weakness should be asked if they have a recent cold or fever. 2. The patient should be asked whether there is eye distension, fever, check whether the patient has cervical ankylosis, need to go to the hospital to do cranial magnetic resonance examination or lumbar puncture examination to understand whether there is intracranial infection. 3, brain hemorrhage: the patient appears headache, nausea, vomiting, weakness, ask the patient whether there is hypertension, diabetes, need to go to the hospital to do cranial CT examination to understand whether there is brain hemorrhage.