Commonly used drugs in the early drug treatment of ankylosing spondylitis include non-steroidal anti-inflammatory drugs (NSAIDs) and anti-rheumatic drugs such as celecoxib and infliximab. 1. Non-steroidal anti-inflammatory drugs: common non-steroidal anti-inflammatory drugs include celecoxib, etoricoxib, ibuprofen, meloxicam and so on, this kind of non-steroidal anti-inflammatory drugs on ankylosing spondylitis can play a role in relieving the patient’s symptoms of morning stiffness, joints swelling and pain and back pain, but the use of such drugs need to pay attention to the risk of gastrointestinal bleeding, ulcer and so on. 2. Anti-rheumatic drugs: common anti-rheumatic drugs in the treatment of ankylosing spondylitis include biologics such as infliximab and adalimumab, and traditional synthetic drugs such as leflunomide and methotrexate, which can roughly alleviate the symptoms of joints and control the patient’s condition. The above drugs should be used under the guidance of a physician, and it is recommended that patients go to the rheumatology and immunology departments of regular hospitals for detailed consultation.