Fifty-something years old at night sleep penis always abnormal erection, first of all, need to take medication, surgical treatment. Secondly, sleeping penis abnormal erection may be caused by sickle cell disease, leukemia, need to take medication, surgical treatment. 1. Direct treatment: patients can use alpha-adrenaline, such as dopamine, mesalamine, etc., and anti-androgen drugs, such as cyproterone acetate, flutamide, etc., under the guidance of the doctor. Some patients can also take sponge prosthesis implantation surgery, penile cavernous and urethral cavernous shunt, saphenous vein penile cavernous shunt, selective arterial embolization and other treatment. 2. Sickle cell disease: patients in their fifties sleeping at night abnormal erection of the penis is considered to be sickle cell disease patients with anemia crisis, can be timely blood transfusion treatment, some patients can also follow the doctor’s instructions to take low molecular dextrose anhydride and other drugs to improve circulation. 3. leukemia: if the leukemia is caused by patients in their fifties sleep at night penis is always abnormal erection, you can follow the doctor’s prescription with nilotinib, imatinib and other tyrosine kinase inhibiting enzymes. Some patients can also follow the doctor’s prescription with methotrexate, cyclophosphamide and other chemotherapy drugs. In addition, patients can also take hematopoietic stem cell transplantation treatment. Fifty-something years old at night sleep penis always abnormal erection may also be caused by other factors, need different treatment methods, need to timely medical treatment, the doctor will be for the cause of the scientific treatment program.