There is no fastest medication for frequent urination. If it is caused by urethritis, ureteral stones, diabetes mellitus and other diseases, commonly used drugs include antibiotics, antispasmodics, analgesics, insulinotropic agents, alpha glucosidase inhibitors, insulin and so on. If frequent urination is caused by excessive drinking, no medication is needed. 1. Urethritis: If it is gonorrhea urethritis, patients need to follow the doctor’s instructions for the application of benicillin, amoxicillin and other penicillin antibiotics, but also follow the doctor’s instructions for the application of ceftriaxone, ceftazidime and other cephalosporin antibiotics. If it is non-gonococcal urethritis, patients need to follow the doctor’s instructions to apply norfloxacin, ciprofloxacin and other quinolone antibiotics, or azithromycin, roxithromycin and other macrolide antibiotics. 2. Ureteral stones: patients need to follow the doctor’s instructions to apply atropine, scopolamine, scopolamine and other antispasmodic drugs, as well as indomethacin, diclofenac sodium and other non-steroidal analgesic anti-inflammatory drugs. Severe pain is required to comply with medical advice to apply codeine, hydrocodone hydrochloride and other opioid analgesics. 3. Diabetes mellitus: patients need to follow the doctor’s instructions to apply insulin secretion agents, such as glibenclamide, gliclazide, nateglinide, etc., as well as acarbose, voglibose and other α-glucosidase inhibitors. Some of the oral drugs are ineffective, then the application of regular insulin, rapid-acting insulin and other insulin under the guidance of a doctor. Secondly, if the frequent urination is caused by drinking too much water, usually no medication is needed to deal with it, which is a normal physiological phenomenon and can be relieved by itself in a short time. When frequent urination occurs, if excluded as a physiological phenomenon, you should go to the hospital in time for examination and treatment. All of the above drugs should be applied under the guidance of a doctor.