There is a possibility of self-healing from minor triple positive, but the chances are not high. 1. HBV can rarely be completely eradicated after recovery from acute HBV infection, and latent infection can maintain T-cell response for decades after clinical recovery, thus keeping the virus under control. If acute hepatitis B is not controlled, it may develop into chronic hepatitis B. Therefore, acute hepatitis B rarely resolves spontaneously. 2. Chronic HBV infection usually consists of 4 phases: immune tolerance, immune activity (HbeAg-positive infection), inactive chronic HBV infection, and immune activity (HbeAg-negative infection). For patients with perinatally acquired HBV infection, the transition from immune tolerance to immune activity or immunoclearance occurs 10-30 years after infection. During this phase, the rate of spontaneous HBeAg clearance increases to 10-20% per year. Therefore some patients with chronic HBV infection may become HBsAg negative. The delayed HBsAg clearance rate is estimated to be 0.5%-2% per year for patients in Western countries and much lower (0.1%-0.8%) for patients in Asian countries. If the diagnosis of hepatitis B is confirmed, standardized antiviral treatment should be initiated as early as possible to slow down the progression of the disease, and do not blindly wait for self-cure to avoid delays.