It is possible, but not absolute, for a small triplet to turn into a large triplet. The former refers to positive hepatitis B surface antigen (HBsAg), hepatitis B e antibody (anti-HBe), and hepatitis B core antibody (anti-HBC). The latter refers to three positive hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), hepatitis B core antibody (anti-HBC), the difference between the two is that the degree of viral activity and infectivity of major triplets is much higher than that of minor triplets. The difference between the two is that the degree of viral activity and contagiousness is much higher than that of small triplets. The conversion of small triplets to large triplets is usually related to the following factors: 1. The majority of patients can be relieved or even cured after antiviral treatment. However, if you do not grasp the correct indications and methods of drug discontinuation, unauthorized or blind discontinuation of drugs can lead to recurrence of the disease, and then turn into a major triplet; 3, hepatitis B virus mutation: hepatitis B virus replication ability and has a certain mutation ability, long-term control is not ideal, will lead to a certain degree of drug resistance or directly into a major triplet; 4, poor lifestyle: mainly including long-term fatigue, drinking, staying up late, catching cold, and unhealthy diet Such as overeating, hobby of spicy and greasy food, etc., can make Xiaosangyang turn into Daosangyang; 5, other: some special periods, such as pregnancy, low immune function, etc., can be a trigger for Xiaosangyang to turn into Daosangyang.