Body wasting, chest tightness and chest pain may be due to the occurrence of lung infection, mediastinal tumor and other diseases, which can be treated with medication and surgery. 1. Drug treatment: when the patient has lung infection, it will lead to the symptoms of body wasting, chest tightness and chest pain, at this time, the patient needs to go to the hospital to do a detailed examination to determine which kind of disease, if it is an infection, it can be treated with anti-infection therapy under the guidance of the doctor, using drugs such as levofloxacin, amoxicillin and other drugs for treatment. 2. Surgery: when mediastinal tumor occurs, it will also lead to wasting, chest pain and chest tightness, at this time, the patient should take surgery for treatment, and after removing the tumor, radiotherapy can be added if needed. When the patients have the symptoms of weight loss, chest pain and chest tightness, they should go to the hospital for examination, clarify the cause of the disease and follow the doctor’s instruction to receive treatment.