The trigeminal nerve is the fifth of 12 pairs of cerebral nerves and is one of the mixed cerebral nerves, consisting of two fibrous components. Trigeminal nerve injury is usually caused by inflammatory infection of the trigeminal nerve as well as trauma, and trigeminal neuralgia as well as trigeminal neuritis are likely to occur after trigeminal nerve injury. Patients with trigeminal neuralgia may experience explosive, transient, electric shock-like severe pain in the face. Trigeminal neuritis is mainly a persistent and slow pain in the face, which may be burning or pulling pain. Since pain and nociceptive hypersensitivity in the forehead, flanks, corners of the mouth, and jaw angle can occur after trigeminal nerve injury, it may affect some patients’ ability to wash their faces, brush their teeth, and eat. For trigeminal neuralgia, medication is preferred and minimally invasive surgery is performed for those who cannot be relieved. In the case of trigeminal neuritis, medication, closure therapy if necessary, as well as acupuncture treatment in Chinese medicine, etc. are required.