Trigeminal neuralgia is a recurrent severe pain that occurs within the distribution of the trigeminal nerve. It comes on suddenly without any aura and is often accompanied by facial muscle twitching, lacrimation, salivation, facial flushing, and conjunctival congestion. Many triggering factors, such as brushing teeth, washing face, talking, and cold stimulation, can cause attacks. The pain is episodic electric shock-like, knife-like, or tearing-like severe pain, which comes and goes suddenly, usually without warning, and the intervals are completely normal. The pain lasts from a few seconds to 1~2 minutes, and the interval between attacks is gradually shortened and the pain is gradually increased. Frequent attacks may affect eating and rest. In severe cases, it is often accompanied by reflex twitching of the facial muscles and the corners of the mouth are drawn to one side, which is also called “painful twitching”. The diagnosis is based on the location, nature, trigger point, degree, time and trigger of the above pain, and there are no positive signs of the nervous system, but it should be differentiated from the following diseases: 1, toothache: trigeminal neuralgia is often misdiagnosed as toothache, and often the healthy teeth are removed, or even all the teeth are removed, so it should be noted. The pain caused by dental disease is persistent, mostly confined to the gingival area, localized with toothache and pathogenic lesions, X-ray and dental examination can confirm the diagnosis…. 2.Glaucoma: acute attack of unilateral glaucoma is misdiagnosed as trigeminal nerve branch 1 pain, glaucoma is persistent pain, not radiating, there may be vomiting, accompanied by congestion of the spherical conjunctiva, shallowing of the anterior chamber and increased intraocular pressure. 3.Migraine: The pain area is beyond the range of trigeminal nerve. Before the attack, there are mostly visual aura, such as blurred vision, dark spots, etc., which may be accompanied by vomiting. The pain is persistent and long, often half a day to 1-2 days. 4, trigeminal neuritis: can be caused by acute maxillary sinusitis, influenza, frontal sinusitis, mandibular osteomyelitis, diabetes, syphilis, typhoid, alcoholism, lead poisoning and food poisoning and other diseases. Most often there is a history of inflammatory infection with a short history, the pain is persistent and can be exacerbated by local compression of the infected branch, and on examination there is hyperalgesia or hypersensitivity of the affected trigeminal nerve subdivision. It may be accompanied by motor disorder. 5.Tumor invasion of skull base: most common is nasopharyngeal carcinoma, often accompanied by epistaxis and nasal congestion, which can invade most of the brain nerves and enlarged cervical lymph nodes. Trigeminal neuralgia treatment methods are mainly the following: 1, drug treatment is the most used trigeminal neuralgia is one of the most commonly used treatment methods, many patients in the beginning of the use of carbamazepine, the treatment effect is okay, can temporarily relieve pain; with the extension of time, drug resistance, the treatment effect is getting worse and worse, the side effects are more and more obvious, at this time patients taking drugs to increase the amount or switch to other drugs Still can not effectively control pain, need to consider early surgical treatment or non-invasive gamma knife treatment. 2, microvascular decompression surgery treatment is suitable for patients whose drug treatment effect has decreased or who have clinical symptoms of vascular compression (MRI can clearly find that the trigeminal nerve root is compressed by blood vessels), these patients can undergo microvascular decompression surgery treatment, microvascular decompression surgery is widely applicable to the population, and the exact effect of surgery, and is now widely used in clinical practice. 3.Radiofrequency thermal coagulation treatment is to use a special long needle to puncture to the location of the trigeminal nerve root, and use radiofrequency instrument to heat to about 80 degrees, so that the nerve degeneration necrosis, to achieve the purpose of blocking the pain transmission. During the treatment process, patients will experience and need to endure severe pain. 4. Closure therapy is also a relatively common treatment method, which uses chemical drugs or anesthetics to inject into the pain-related branches of the trigeminal nerve, temporarily blocking nerve conduction to achieve the purpose of pain relief, but the general control time is short, easy to relapse, and also affected by the doctor’s treatment experience, if the doctor is inexperienced or operation error may lead to serious consequences. 5.Gamma radiation therapy has been studied and clinically used at home and abroad, using a certain dose of radiation irradiation nerve nociceptive conduction can achieve the purpose of treating pain, but also does not damage the function of the trigeminal nerve, but the specific operation is more difficult, there is room for further development.