Mycoplasma infections in children can be treated with oral azithromycin, usually depending on the severity of the mycoplasma infection, and generally require 3-4 courses of treatment. If the child’s immune function is poor and recurrent mycoplasma infections occur, the specific course of treatment may be extended appropriately, so the specific treatment should be based on the child’s immune function and symptoms. Usually a course of azithromycin is used for 3 days, and can be used again after a 4-day stop. If clinical cure is achieved when the child has no symptoms, the principle is that the medication can be stopped. During the recovery period, care must be taken to avoid recurrent infections in the child and the reappearance of fever, cough and other corresponding symptoms due to mycoplasma infection, when azithromycin is needed again for treatment. However, repeated application of azithromycin for treatment can cause damage to the liver function of the child, so in addition to oral medication, the immune function of the child can be adjusted appropriately.